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. 2024 Mar 26;15(4):416. doi: 10.3390/genes15040416

Figure 5.

Figure 5

TMEM106B mRNA levels measured in human temporal cortices affected with different neuropathologies. TMEM106B mRNA levels were measured by RNAseq in the Mayo Clinic cohort. Mean ± SEM (shaded area) are presented for four groups of individuals, each with a different diagnostic. TMEM106B mean expression increased progressively from CU (10.76 ± 0.62 CPM; n = 74), to PSP (11.25 ± 0.43 CPM; n = 82), PA (12.13 ± 1.27 CPM; n = 30) and finally AD (13.10 ± 0.44 CPM; n = 80). TMEM106B mRNA levels were elevated in AD compared to CU (p = 0.002) and PSP (p = 0.003).