Table 1.
Top TMEM106B pQTL SNPs and their associations with different neuropathological conditions.
| SNP | Location | Disease | Ref. |
|---|---|---|---|
| rs3173615 | Exon 6 | FTL-TDP, CTE, PD | [30,31,32,33] |
| (T185S) | |||
| rs13237518 | intron | AD, T2D | [34,35] |
| rs1548884 | 3′UTR | ||
| rs1990622 | downstream | FTLD-TDP, ALS, AD, PD, HipScl | [33,36,37,38,39,40,41,42,43,44,45,46] |
Abbreviations: FTLD-TDP—frontotemporal lobar degeneration with TAR DNA binding protein inclusions; CTE—chronic traumatic encephalopathy; PD—Parkinson’s disease; AD—Alzheimer’s disease; T2D—type 2 diabetes; ALS—amyotrophic lateral sclerosis; HipScl—hippocampal sclerosis.