Table 4.

ASTCT CRS Consensus Grading [148].

CRS	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Fever (not attributable to other causes)	≥38 °C	≥38 °C	≥38 °C	≥38 °C	Death
With
Hypotension	None	Not requiring vasopressors	Requiring a vasopressor with or without vasopressin	Requiring multiple vasopressors (excluding vasopressin)	Death
And/or
Hypoxia	None	Requiring low-flow nasal cannula or blow-by	Requiring high-flow nasal cannula, facemask, nonrebreather mask, or venturi mask	Requiring positive pressure (e.g., CPAP, BiPAP, intubation, and mechanical ventilation)	Death

Abbreviations: BiPAP, bilevel positive airway pressure; CPAP, continuous positive airway pressure; CRS, cytokine release syndrome.