Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of pyrrolo-pyrazole derivatives 3, peptidomimetics 4, and 5/5′ reagents and conditions. (i) Et2O, 25 °C, 12 h; (ii) Method A: Fmoc-GlyOH (1.2 mmol.; 0.05 M in CH2Cl2)/EDC (1.3 mmol)/HOBt (1.3 mmol)/1 h, 0 °C, then DIPEA (pH 7–8)/3 (1 mmol) 25 °C, overnight; Method B: Fmoc-AlaOH (1.9 mmol; 0.01 M in CH2Cl2)/DIC (2.1 mmol)/OXIMA (2.1 mmol)/1 h, 0 °C, then 3 (1.5 mmol)/DIPEA (pH 7–8), 25 °C, overnight.
