Table 2.
Characteristics of the included patients, their tumors and the FUS procedures. Tumor type was converted into (likely) WHO2021 diagnosis wherever possible. Abbreviations: IDH = isocitrate dehydrogenase, TERT = telomerase reverse transcriptase; MGMT = O-6-methylguanine-DNA methyltransferase; FUS = Focused ultrasound; MI = Mechanical index; # = number of FUS procedures.
| Study | Patient | Tumor Type | FUS Procedures | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | Age | Sex | Type | TERT | MGMT Promotor | # | Sonication Volume (cm3) | Estimated MI | |
| [35] | G01 | 73 | M | Glioblastoma, IDH-wildtype | C228T | n.r. | 1 | 0.13 | 0.58 |
| G02 | 58 | M | Glioblastoma, IDH-wildtype | C250T | n.r. | 1 | 0.13 | 0.38 | |
| G03 | 66 | F | Glioblastoma, IDH-wildtype | C228T | n.r. | 1 | 0.13 | 0.8 | |
| G04 | 66 | M | Glioblastoma, IDH-wildtype | C250T | n.r. | 1 | 0.13 | 0.66 | |
| G05 | 36 | M | High-grade glioma NOS, IDH-wildtype | Wild type | n.r. | 1 | 0.13 | 0.5 | |
| [33] | P1 | 49 | F | Glioblastoma, IDH-wildtype | n.r. | NA | 4 | 3.75 | n.r. |
| P2 | 52 | M | Glioblastoma, IDH-wildtype | n.r. | Methylated | 6 | 4.28 | n.r. | |
| P3 | 56 | F | Glioblastoma, IDH-wildtype | n.r. | Unmethylated | 4 | 2.48 | n.r. | |
| P4 | 35 | M | Glioblastoma, IDH-wildtype | n.r. | NA | 3 | 4.97 | n.r. | |
| P5 | 56 | F | Glioblastoma, IDH-wildtype | n.r. | Unmethylated | 4 | 6.88 | n.r. | |
| P6 | 42 | F | Astrocytoma, IDH-R132-H-mutant, grade 4 | n.r. | NA | 6 | 8.13 | n.r. | |
| P7 | 40 | F | Glioblastoma, IDH-wildtype | n.r. | Unmethylated | 4 | 9.08 | n.r. | |
| P8 | 36 | F | Glioblastoma, IDH-wildtype | n.r. | Unmethylated | 5 | 21.16 | n.r. | |
| P9 | 68 | M | Glioblastoma, IDH-wildtype | n.r. | Methylated | 2 | 5.55 | n.r. | |