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Temporal development of immunoglobulin reactivity to peptides representative of different V3 loops of gp120. V3-specific antibodies were detected by ELISA in sequential sera of seropositive individuals at various times after seroconversion. The OD450–650 values are the means from three separate experiments performed with the sera from patients Bx08 (⧫), Bx16 (■), Bx17 (▴), and Bx26 (•). Solid line, cutoff value.
