Table 3.
Clinical predictors of 28-d in-hospital mortality in DSS children from univariable and multivariable logistic regressions with covariates in the first 24h of PICU admission
| Factors | Nonsurvivors (n = 26) |
Survivors (n = 466) |
Unadjusted OR (95% CI), P value |
Adjusted OR (95% CI), P value |
|---|---|---|---|---|
| Age (yr) | 7.5 (5.9–10) | 7.6 (5–10) | 1.02 (0.92–1.14), P = .69 |
- |
| Gender | ||||
| Male | 15 (58) | 223 (48) | 0.67 (0.3–1.5), P = .33 |
- |
| Female | 11 (42) | 243 (52) | ||
| Dengue severity* | ||||
| Compensated DSS | 18 (69) | 410 (88) | 3.95 (1.73–9.0), P = .001 |
- |
| Decompensated DSS | 8 (31) | 56 (12) | ||
| Respiratory rate (breaths/min) | 30 (24–35) | 26 (24–30) | 1.03 (0.98–1.08), P = .19 |
- |
| Severe bleeding* | ||||
| No | 7 (27) | 418 (90) | 23.6 (9.5–59.1), P < .001 |
4.14 (1.25–13.7), |
| Yes | 19 (73) | 48 (10) | P = .02 | |
| Severe liver transaminases* | ||||
| No | 8 (31) | 399 (86) | 13.4 (5.6–32.1), P < .001 |
- |
| Yes | 18 (69) | 67 (14) | ||
| Peak hematocrit level (%) | 48 (42–52) | 48 (45–51) | 0.97 (0.91–1.04), P = .41 |
- |
| Low platelet cell count, (< 20,000 cells × 109/L) |
||||
| No | 12 (46) | 361 (77) | 4.0 (1.8–8.91), P < .001 |
- |
| Yes | 14 (54) | 105 (23) | ||
| Serum creatinin (µmol/L) | 68 (58–123) | 50 (42–58) | 1.03 (1.02–1.05), P < .001 |
- |
| High VIS (> 30) No Yes |
5 (19) 21 (81) |
452 (97) 14 (3) |
135 (45–412), P < .001 |
36.2 (10.7–122.3), P < .001 |
| Square root of cumulative amount of infusion fluid from referral hospitals and 24h PICU admission (mL/kg)† | 16 (14–18) | 11 (9–13) | 1.36 (1.21–1.52), P < .001 |
1.18 (1.04–1.34), P = .01 |
Summary statistics are median (IQR) for continuous variables and frequency (%) for categorical data.
CI = confidence interval; DSS = dengue shock syndrome; OR = odds ratio, PICU = pediatric intensive care unit; VIS = vasoactive-inotropic score, WHO = World Health Organization.
*
These factors were defined by the WHO dengue guidelines in 2009.
†
Standardized covariate of the cumulative amount of fluid from referral hospitals and within 24h PICU admission by square root.