Table 5.

Performance of predictive models with internal validation.

Predictive models	C-statistic	Calibration slope	Brier score
Clinical predictors-based model (1)*	0.954 (0.946)	1 (0.961)	0.023 (0.024)
(1) + Blood lactate	0.950 (0.940)	1 (0.915)	0.026 (0.029)
(1) + Blood L/B ratio	0.942 (0.924)	1 (0.925)	0.027 (0.029)

Statistics are summarized for training (test) sets performed with bootstrap and internal validation

L/B = serum lactate/bicarbonate ratio, PICU = pediatric intensive care unit.

^*Based on clinically developed model, with identified predictors including severe bleeding, cumulative amount of fluid infused from referral hospitals and 24h PICU admission, and high vasoactive-inotropic score (>30).