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(A) The chromosomal territory area (CTA; normalized to the whole nucleus area) is significantly higher in patients with low (median: 0.349, 95% CI [0.17 0.54]) than high score (median 0.20, 95% CI [0.09 0.32], p < 0.00001). (B) The CTA value distribution in subjects with low (orange) and high (blue) scores shows a more limited overlap, with values > 0.4 observed only in spermatozoa with low scores.
