Table 3.
The 10 most significant GO biological processes and canonical pathways for the top FDR-significant 10% heritable genes (n = 460).
| GO Biological Processes/Canonical Pathways | N Genes in Pathway | N Genes Overlap | FDR |
|---|---|---|---|
| REACTOME_NEUTROPHIL_DEGRANULATION | 389 | 51 | 7.82 × 10−16 |
| REACTOME_INNATE_IMMUNE_SYSTEM | 826 | 66 | 2.17 × 10−10 |
| REACTOME_ANTIMICROBIAL_PEPTIDES | 56 | 13 | 7.59 × 10−6 |
| GOBP_ANTIMICROBIAL_HUMORAL_RESPONSE | 80 | 16 | 1.10 × 10−5 |
| GOBP_IMMUNE_RESPONSE | 1237 | 73 | 3.81 × 10−5 |
| GOBP_ANTIMICROBIAL_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_ANTIMICROBIAL_PEPTIDE | 53 | 12 | 9.82 × 10−5 |
| GOBP_DEFENSE_RESPONSE | 1297 | 73 | 1.27 × 10−4 |
| GOBP_DEFENSE_RESPONSE_TO_BACTERIUM | 212 | 23 | 1.27 × 10−4 |
| GOBP_INFLAMMATORY_RESPONSE | 645 | 45 | 1.27 × 10−4 |
| GOBP_HUMORAL_IMMUNE_RESPONSE | 168 | 19 | 7.2 × 10−4 |