Table 1.
Summary of completed interventional studies with results.
| ClinicalTrials.gov ID | Official Title | Intervention | Phase | (Estimated) Completion | Enrollment | Ref. |
|---|---|---|---|---|---|---|
| NCT05224453 | Comparative Effects of Integrated Physical Training With High Protein Diet Versus Low Protein Diet in COVID-19 Asymptomatic Older Adults With Sarcopenia Symptoms. | Other: Physical training and high protein diet Other: Physical training and low protein diet |
N/A | 30 November 2021 | 76 | [126] |
| NCT03809104 | Virtual Reality-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents in Caring Facilities—a Pilot Study in Rural Southern Taiwan | Other: Virtual reality-based rehabilitation programs | N/A | 8 October 2019 | 43 | [127] |
| NCT02628145 | Effects of a Resistance Training Program in Older Women With Sarcopenia | Behavioral: Resistance Training Intervention Behavioral: Active Control Group |
N/A | July 2016 | 25 | [128] |
| NCT02333331 | A 28 Week, Randomized, Double-blind, Placebo-controlled, Two-part, Multi-center, Parallel Group Dose Range Finding Study to Assess the Effect of Monthly Doses of Bimagrumab 70, 210, and 700 mg on Skeletal Muscle Strength and Function in Older Adults With Sarcopenia (InvestiGAIT) | Drug: bimagrumab Other: placebo |
2 | 28 June 2018 | 217 | [129] |
| NCT00529659 | A Phase IIa Randomized, Placebo-Controlled Clinical Trial to Study the Efficacy and Safety of MK-0773 in Patients With Sarcopenia | Drug: Comparator: MK-0773 Drug: Comparator: Placebo |
2 | October 2009 | 170 | [130] |
| NCT02468674 | A 24 Week Off Drug Extension, Parallel Group, Study Assessing Durability of Effect on Skeletal Muscle Strength and Function Following a 6-month Double-blind, Placebo Controlled Study Evaluating Bimagrumab in Older Adults With Sarcopenia (InvestiGAIT Extension) | Drug: bimagrumab Drug: Placebo |
2 | 3 December 2018 | 160 | [131] |
| NCT04830514 | Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics | Other: Recommended Dietary Allowance of Protein Other: Habitual protein intake Other: Optimal Protein Intake |
N/A | 15 March 2015 | 44 | [132] |
| NCT01989793 | A Study of Muscle Strength Maintenance in Older Adults | Drug: Losartan Drug: Placebo |
2 | October 2016 | 37 | [133] |
| NCT03502941 | Effect of an Essential Amino Acid/Protein Composition on Protein Metabolism | Dietary Supplement: 6.3 g of EAAs mixture and whey protein isolate Dietary Supplement: 12.6 g of EAAs mixture and whey protein isolate Dietary Supplement: 12.6 g of whey protein isolate |
N/A | 17 July 2019 | 16 | [134] |
| NCT02692235 | Carnitine Supplementation and Skeletal Muscle Function in Aging | Dietary Supplement: carnitine Dietary Supplement: placebo |
3 | July 2017 | 28 | [135] |
| NCT00957801 | Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men | Drug: Testosterone injection Drug: Testosterone gel Drug: Medrol |
4 | December 2015 | 29 | [136] |
| NCT01032733 | Biological Effects of Weight Loss Plus Exercise in Obese Older African-American Women: An Investigation of Aging-related Changes in Black and White Women | Behavioral: Lifestyle Counseling Other: Educational Control |
2 | October 2009 | 34 | [137] |
| NCT00357214 | Effect of Potassium Bicarbonate on Bone and Muscle | Dietary Supplement: Potassium Bicarbonate Dietary Supplement: Sodium Bicarbonate Dietary Supplement: Potassium Chloride Dietary Supplement: placebo (microcrystalline cellulose) |
N/A | April 2008 | 171 | [138] |
| NCT02617511 | Omega-3 Fatty Acid Supplementation and Resistance Training on Inflammation and Body Composition in Older Men | Dietary Supplement: Omega-3 Supplementation Dietary Supplement: Placebo |
N/A | November 2016 | 24 | [139] |
| NCT01083901 | Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training | Behavioral: Resistance training | N/A | March 2011 | 34 | [140] |
| NCT02261961 | Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults | Biological: TDAP Other: Acute Resistance Exercise Other: Resistance Exercise Training Other: Post-training Follow-up Dietary Supplement: Nutritional Supplement (Muscle Armor) Dietary Supplement: Placebo (Kool-Aid) |
N/A | 30 September 2019 | 59 | [141] |
| NCT03579693 | Cross-over Randomized Controlled Trial of Coenzyme Q10 or Nicotinamide Riboside in Chronic Kidney Disease | Dietary Supplement: CoQ10 Dietary Supplement: Nicotinamide riboside Dietary Supplement: Placebo |
2 | 26 April 2021 | 26 | [142] |
| NCT00104572 | The Effects of Aromatase Inhibition and Testosterone Replacement in Sex Steroids, Pituitary Hormones, Markers of Bone Turnover, Muscle Strength, and Cognition in Older Men | Drug: Androgel (Testosterone Gel) Drug: Anastrozole (Aromatase Inhibitor) Drug: Placebo tablet Drug: Placebo gel Dietary Supplement: Calcium Cardone 500 mg with vitamin D 400 IU |
2 | January 2015 | 44 | [143] |
| NCT01869348 | IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial | Behavioral: Monitor intervention | N/A | 15 April 2016 | 40 | [144] |
| NCT03119610 | The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity | Drug: Oxytocin nasal spray Drug: Placebo nasal spray |
1/2 | 17 December 2019 | 23 | [145] |
| NCT00475501 | 5-Alpha Reductase and Anabolic Effects of Testosterone | Drug: Testosterone Enanthate Drug: Finasteride Other: Placebo |
2 | October 2014 | 60 | [146] |
| NCT02838979 | Randomized Cross-over Trial of Oral L-Glutamine vs. Maltodextrin on Mitochondrial Function in Chronic Kidney Disease | Dietary Supplement: First Intervention (14 days) Other: Washout (3 weeks) Dietary Supplement: Second Intervention (14 days) |
2 | 31 January 2018 | 11 | [147] |
| NCT02776553 | A Physical Activity Program in End-stage Liver Disease: Pilot Study Assessing Changes in Physical Fitness, Sarcopenia, and the Metabolic Profile | Other: Nutritional consultation Behavioral: Physical training program Behavioral: Behavioral modification therapy |
N/A | June 2020 | 20 | [148] |
| NCT01874132 | A Randomised Longitudinal Study of Exercise Prescription for Older Adults: Mode and Intensity to Induce the Highest Cardiovascular Health-related Benefits | Behavioral: Exercise training | N/A | September 2014 | 66 | [149] |