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. 2024 Apr 18;25(8):4453. doi: 10.3390/ijms25084453

Table 3.

Comparison of existing and proposed classification criteria for ASyS and IIM, adapted from Opinc, 2021 [3] and Marco, 2020 [36].

Solomon et al., 2011 [30] Connors et al., 2010 [35] EULAR/ACR 2017 [34]
Antisynthetase antibody plus two major criteria or one major and two minor criteria: Antisynthetase antibody plus one or more of the following: Definite IIM: score of at least 7.5 (8.7 with muscle biopsy)
Probable IIM: score of at least 5.5 (6.7 with muscle biopsy)
  • Major Criteria
    • Myositis by Bohan and Peter [33]
    • ILD
  • Minor Criteria
    • Arthritis
    • Raynaud’s phenomenon
    • Mechanic’s hands
  • Myositis by Bohan and Peter [33]

  • ILD

  • Arthritis

  • Raynaud’s phenomenon

  • Mechanic’s hands

  • Persistent unexplained fever

  • Anti-Jo-1

  • Objective symmetrical weakness of upper and lower proximal extremities

  • Proximal leg muscles weaker than distal

  • Dysphagia or esophageal motility disorders

  • Skin lesions (heliotrope rash, Gottron’s papules, and Gottron’s sign)

  • Age of onset

  • Typical features in muscle biopsy and elevated skeletal muscle enzymes