Table 8.

Phenotypes of ASyS by ASAb specificities.

Predominant Feature		Antisynthetase Antibodies	Common Phenotype
Arthritis Myositis ILD		Anti-Jo-1	Isolated arthritis common [14] Mild myositis [76] ILD with NSIP pattern; overall, less severe with improved overall survival [29,44,69] Mechanic’s hands common [76]
		Anti-OJ	Often isolated myositis or ILD [43,81] Myositis tends to be severe [32,81] ILD with NSIP, OP, or UIP [69,79]
		Anti-PL7	More severe ILD with NSIP or UIP pattern [69,79] Myositis common [29,44] More frequent GERD and dysphagia [29]
		Anti-PL12	More severe ILD with NSIP or OP pattern [69,79] Myositis common [29,44] More frequent GERD and dysphagia [29]
		Anti-EJ	Isolated ILD with NSIP or OP pattern [69,79]
		Anti-KS	Isolated ILD with NSIP or UIP pattern [83,84]
		Anti-HA/YRS and Anti-Zo	Not enough information is known