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. 2024 Apr 12;25(8):4291. doi: 10.3390/ijms25084291

Figure 1.

Figure 1

Plasma miRNA profiles revealed three subgroups of schizophrenia patients. (A) Heatmap shows expression levels of all the 179 miRNAs and scores of PANSS total (PANSS T), a positive symptom subscale (PANSS P), a negative symptom subscale (PANSS N), and a general psychopathy subscale (PANSS GP). Dendrogram visualizes Euclidean distance of miRNA profiles among samples obtained from schizophrenia patients. (B) Distinctive miRNAs in each subgroup (red frames) were extracted as differentially expressed miRNAs between one subgroup and the other subgroups (two-tailed unpaired t-test, Benjamini–Hochberg corrected p < 0.001). ‘1-up’ is the upregulated miRNA in subgroup 1. ‘1-down’ is the downregulated miRNAs in subgroup 1. ‘2-down’ is the downregulated miRNAs in subgroup 2. ‘3-up’ is the upregulated miRNAs in subgroup 3. ‘3-down’ is the downregulated miRNAs in subgroup 3. (C) Box-and-swarm plots show expression levels of a representative miRNA in each subgroup.