Figure 2.

Subgroups 1 and 2 were inferred to have high levels of pro-inflammatory cytokines, whereas subgroup 3 was inferred to have low levels of pro-inflammatory cytokines. Subgroups 1 and 2 had low levels of the miRNAs mapped in ‘inflammation’ or ‘Immune response’, which were reported to downregulate IL-1β, IL-6, and TNFα. Subgroup 3 had low levels of the miRNAs mapped in ‘Immune System’, which were reported to downregulate IL-1β, IL-6, and TNFα. In addition, subgroup 3 had high levels of the miRNAs mapped in ‘inflammation’, some of which were reported to upregulate IL-1β, IL-6, and TNFα. Most of the miRNAs mapped in ‘Immune Response’ or ‘Immune System’ in subgroups 2 and 3 were overlappingly mapped in ‘brain.cerebellum’. A standard arrow indicates a positive or activating interaction, while a flat-headed arrow represents a negative or inhibitory interaction.