Table 2.
Enriched pathways/tissues by distinctive miRNAs in each subgroup.
| miRNA Sets | Enriched Pathways/Tissues | Nmapped/Npredefined | q-Values |
|---|---|---|---|
| Upregulated 1 miRNA in subgroup 1 | No item was significantly enriched | - | - |
| Downregulated 3 miRNAs in subgroup 1 |
Aging | 3/63 | 2.49 × 103 |
| Epithelial-to-Mesenchymal Transition | 3/83 | 3.81 × 103 | |
| Inflammation | 3/112 | 4.00 × 103 | |
| Downregulated 4 miRNAs in subgroup 2 |
brain.cerebellum | 5/21 | 3.24 × 108 |
| Immune Response | 6/92 | 3.27 × 107 | |
| Angiogenesis | 5/65 | 4.29 × 106 | |
| Cell Death | 5/78 | 8.18 × 106 | |
| Cell Cycle | 5/83 | 8.95 × 106 | |
| Apoptosis | 5/106 | 2.58 × 105 | |
| Neurotoxicity | 3/20 | 1.31 × 104 | |
| Regulation of Akt Pathway | 3/26 | 2.59 × 104 | |
| Hormone-mediated Signaling Pathway | 3/58 | 1.97 × 103 | |
| Upregulated 10 miRNAs in subgroup 3 |
brain.cerebellum | 7/21 | 2.29 × 1010 |
| Aging | 6/63 | 2.09 × 105 | |
| Angiogenesis | 5/65 | 4.79 × 104 | |
| T-Cell Differentiation | 3/16 | 1.48 × 103 | |
| Cell Division | 3/17 | 1.48 × 103 | |
| Neurotoxicity | 3/20 | 2.03 × 103 | |
| Immune System | 3/21 | 2.03 × 103 | |
| Hematopoiesis | 4/57 | 2.15 × 103 | |
| Downregulated 22 miRNAs in subgroup 3 |
kidney.cortex_renalis | 7/41 | 2.20 × 105 |
| Neuron Apoptosis | 4/15 | 9.75 × 104 | |
| DNA Damage Response | 4/16 | 9.75 × 104 | |
| Adipocyte Differentiation | 5/41 | 1.98 × 103 | |
| Cholesterol Hydrolysis | 2/2 | 1.98 × 103 | |
| Cholesterol Influx | 2/2 | 1.98 × 103 | |
| Cholesterol Esterification | 2/2 | 1.98 × 103 | |
| Peritoneal Cavity Homeostasis | 4/23 | 1.98 × 103 | |
| Placenta | 3/11 | 3.21 × 103 | |
| Inflammation | 7/112 | 3.58 × 103 |
Nmapped, number of mapped miRNAs; Npre-defined, number of pre-defined miRNAs in each pathway; q-values, Benjamini–Hochberg corrected p-values. The most significant ten pathways/tissues in terms of q-values were displayed. The number of mapped miRNAs could be larger than the number of query miRNAs because some miRNAs in the query (e.g., hsa-miR-194-5p) were automatically mapped to all of the duplicated miRNA genes (e.g., hsa-miR-194-1 and hsa-miR-194-2).