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. 2024 Mar 29;15(4):432. doi: 10.3390/genes15040432

Figure 3.

Figure 3

Anticoagulant response of PC, PS and FV assessed as ratio of sensitivity to APC (APC-sr) of different scalar dilutions (0–100%) in comparison to that of FV-Leiden and FVIII. Black, pink and light-blue diamonds (on the left), show the undiluted APC sensitivity ratios of the three family members (II1, II2, and III1, respectively). “FV Leiden” indicates FV 506QQ sample dilution with normal pool plasma, and “FV Leiden 2” indicates FV 506QQ sample dilution in FV-immune-depleted plasma as detailed in the Methods section. Note that, to obtain measurable APTT seconds, the lowest proportion of “FV Leiden 2” in FV-deficient plasma starts at 5% of factor defect (%), similarly the highest dilution of “FV” ends at 95% of factor defect (%), this because both samples cannot yield measurable APTT seconds at FV concentration below 5%. The remaining samples are in the full range (0–100%).