Table 1.
Members of the human lipocalin family.
| Protein | Alias | Chromosomal Localization |
Predicted Function |
|---|---|---|---|
| LCN1 | Tear lipocalin (TLC), tear prealbumin (TP), protein migration faster than albumin (PMFA); von Ebner gland protein (VEGP) | 9q34 | Removal of potentially harmful lipids, overproduced in infection ad stress, tear lipocalin |
| LCN2 | Neutrophil gelatinase-associated lipocalin (NGAL), oncogenic lipocalin (24p3), uterocalin, MSFI, siderocalin (Scn) | 9q34.11 | Transport of small lipophilic substances, innate immunity, iron metabolism |
| LCN6 | LCN5, hLcn5, UNQ643/PRO1273 | 9q34.3 | Epididymal lipocalin involved in male fertility and single fertilization |
| LCN8 | EP17, Epididymis secretory sperm binding protein, LCN5, Chromosome 9 open reading frame 137 | 9q34.3 | Sperm maturation via transport of small hydrophobic molecules, male fertility, retinoid carrier protein within epididymis |
| LCN9 | Epididymis luminal protein 129 (HEL129), epididdymal-specific lipocalin-9, 9230102I19Rik, MUP-like lipocalin | 9q34.3 | Binding small hydrophobic ligands |
| LCN10 | 9230112J07Rik, Epididymal-specific lipocalin-10 | 9q34.3 | Protects against inflammation triggered vascular leakage. |
| LCN12 | Epididymal-specific lipocalin-12, MGC48935, epididymis secretory sperm binding protein | 9q34.3 | Male fertility, binds all-trans retinoic acid within epididymis |
| LCN15 | PRO6093, UNQ2541 | 9q34.3 | Olfactory mucus, transport of vitamins, nucleosides |
| A1M | α1-microglobulin, α1-microglobulin/bikunin precursor (AMBP), heterogenous charge protein (HCP), complex-forming glycoprotein heterogeneous in charge, ITI, UTI, EDC1, HI30, ITIL, IATIL, ITILC, uristatin, uronic-acid-rich protein, trypstatin, growth-inhibiting protein 19, MGC64242, AI194774, DKFZp470D2211 | 9q32-q33 | Antioxidant, heme binding, radical scavenging |
| PTGDS | Prostaglandin D2 synthase, PGD2, PDG2 synthase, (PDS, PGDS, PGDS2), lipocalin-type prostaglandin D synthase (LPGDS, L-PGDS) | 9q34.2-q34.3 | Catalyzes PGD2 production and transports lipophilic substances |
| ORM1 | Orosomucoid 1 (ORM), α-1-AGP (AGP1), α- 1-glycoprotein α (AGP-A), HEL-S-153w | 9q32 | Tissue homeostasis and remodeling, acute phase reactant |
| ORM2 | Orosomucoid 2, α-1-acid glycoprotein type 2 (AGP2), α1-glycoprotein β (AGP-B) | 9q32 | Acute phase reactant, immunomodulation and drug delivery, biomarker in cancers |
| OBP2A | Odorant-binding protein 2A, ddorant-binding protein (OBP), LCN13, OBP2C, OBPIIa, HOBPIIa | 9q34 | Scavenger of toxic odors, transport of hydrophobic molecules to olfactory receptors |
| OBP2B | Odorant-binding protein-2B, LCN14, OBPIIb | 9q34 | Chemosensory behavior |
| C8G | Complement component 8, γ subunit | 9q34.3 | Formation of membrane attack complex of the complement |
| PAEP | Progestagen-associated endometrial protein, glycodelin-S (GD-S), glycodelin-A (GdA); glycodelin-F (GdF), glycodelin-S (GdS), PEP; progestagen-dependent endometrial protein (PAEG), placental protein 14 (PP14) | 9q34 | Cell recognition, epithelial differentiation |
| RBP4 | Retinol-binding protein-4, retinol-binding protein, retinal dystrophy iris coloboma and comedogenic acne syndrome protein (RDCCAS), microphthalmia/coloboma 10 (MCOPCB10) | 10q23.33 | Transport of the all-trans form of vitamin A |
| ApoD | Apolipoprotein D | 3q29 | Lipid metabolism, neuroprotection |
| ApoM | Apolipoprotein M, G3a, NG20, HSPC336 | 6p21 | Anti-atherosclerotic, cholesterol efflux |