Table 3.
Haplotype analysis of APOE polymorphisms according to APOE alleles and genotypes in pseudoexfoliation glaucoma (PXG).
| APOE | Controls n (%) |
PXG n (%) |
OR (95% CI) | p |
|---|---|---|---|---|
| Alleles | ||||
| ε3 | 440 (87.6) | 169 (89.9) | 1.00 | - |
| ε2 | 14 (2.8) | 7 (3.7) | 1.30 (0.51–3.28) | 0.557 |
| ε4 | 48 (9.6) | 12 (6.4) | 0.65 (0.33–1.25) | 0.197 |
| Genotypes a | ||||
| ε3/ε3 | 199 (79.3) | 77 (81.9) | 1.00 | - |
| ε2/ε2 | 1 (0.4) | 1 (1.1) | 2.58 (0.16–41.8) | 0.999 |
| ε2/ε3 | 4 (1.6) | 4 (4.2) | 2.80 (0.63–10.60) | 0.230 |
| ε2/ε4 | 8 (3.2) | 1 (1.1) | 0.32 (0.04–2.62) | 0.452 |
| ε3/ε4 | 38 (15.1) | 11 (11.7) | 0.75 (0.36–1.53) | 0.488 |
| ε4/ε4 | 1 (0.4) | 0 (0) | - | 0.999 |
| ε3/ε3 vs. All | 52 (20.7) | 17 (18.0) | 0.85 (0.46–1.55) | 0.583 |
| Carrier b | ||||
| ε3/ε3 | 199 (81.9) | 77 (82.8) | 1.00 | - |
| ε*2 c | 5 (2.0) | 5 (5.4) | 2.58 (0.72–9.17) | 0.156 |
| ε*4 d | 39 (16.0) | 11 (11.8) | 0.72 (0.35–1.49) | 0.489 |
OR—odds ratio, 95% CI—95% confidence interval. a Overall Pearson chi-square = 4.80, df = 5, p = 0.441. b ε2/ε4 were excluded from either ε*2 or ε*4 carrier group. c Includes ε2/ε2 and ε2/ε3. d Includes ε4/ε4 and ε3/ε4.