Table 5.
Haplotypes associated with APOE allele and their frequency distribution in different populations.
| APOE Alleles | ε3 | ε2 | ε4 |
|---|---|---|---|
| Haplotype | rs429358-T rs7412-C |
rs429358-T rs7412-T |
rs429358-C rs7412-C |
| Residue combination | 112-Cys 158-Arg |
112-Cys 158-Cys |
112-Arg 158-Arg |
| Ethnicity | Allele frequency a | ||
| Europeans | 0.640–0.900 | 0.044–0.120 | 0.052–0.310 |
| Asians | 0.620–0.870 | 0.020–0.140 | 0.071–0.240 |
| Africans | 0.536–0.850 | 0.031–0.116 | 0.085–0.407 |
| Native Americans | 0.720–0.911 | 0.0–0.014 | 0.089–0.280 |
| Oceanians | 0.486–0.740 | 0.0–0.145 | 0.260–0.368 |
| Our study (Saudi Arabians) b | 0.876 | 0.028 | 0.096 |