Figure 3.

Molecular changes between EMR1⁺ and EMR1^KO CC cells after coculture with macrophages in vitro. (A) Heatmap of the Directed Global Significance Scores indicating the extent to which a given gene set was upregulated or downregulated relative to a given covariate. The selected covariates are listed along the right side of the heatmap. (B) Heatmap illustrating major DEGs between EMR1⁺ vs. EMR1^KO CC cells with or without macrophage coculture. Abbreviations: CC: colon cancer, DEG: differential expressed gene, KEGG: Kyoto Encyclopedia of Genes and Genomes database, KO: knockout.