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. 2024 Apr 10;25(8):4209. doi: 10.3390/ijms25084209

Figure 4.

Figure 4

The diagram illustrates the HSP90/HSPC protein domain arrangement (above) and HSP90 interacting client proteins (below). (A) HSP90/HSPC consists of three main domains, the ATP binding domain, middle domain, and C-terminal domain. The C-terminal domain contains highly conserved sequences that help in dimerization. (B) HSP90 has many interactors that bind to the middle domain (206–287 amino acids) region and regulate various functions in the cells. Solid ‘→’ shows direct interaction, doted ‘→’ intermittent function.