Figure 7.

The diagram illustrates the domain arrangement of the HSP27/HSPB protein (above), and HSP27-associated functions (below). (A) HSP27, comprising the N-terminal domain, α-crystallin domain, and C-terminal domain. (B) The diagram depicts the HSP27 involved in various cellular pathways. The diagram illustrates HSP27 involved in various crucial processes including mitochondrial integrity, apoptosis, protein folding, and cell cycle regulation. HSP27 interacts with cellular proteins such as Bim, cytochrome C, and DAXX, thereby modulating processes regulated to cancer, neurodegeneration, and apoptosis. Various stressors and chemical and physical stimuli activate downstream signals that regulate protein folding and cell death pathways. Dysfunctional mitochondria and compromised membrane integrity trigger cell death through apoptosis. Red circle: Chemotherapeutic drug; Green circle: Active chemotherapeutic drugs; Marron triangle: Death ligands, Violet circle: Fas-associated Protein death domain; Sky-blue oval: Pro-caspase-8; Red box: Bim.