Figure 5.

C. tropicalis altered the expression of genes involved in multiple immune responses in C. albicans-challenged mice. Heatmaps of the normalized data indicated connections between genes differentially expressed in the colonic tissues of the co-inoculated (Co) mice compared to the mice mono-inoculated with (A) C. tropicalis (Tr) or (B) C. albicans (Al). Data are shown indicating associations between the gene expression (gold, upregulation; blue, downregulation) and treatment. Each row corresponds to a specific probe and each column corresponds to a specific sample. Hierarchical clustering was used to generate dendrograms. Volcano plots expressing the NanoString data for 785 genes showed that the colonic tissues of the co-inoculated mice had (C) nine genes upregulated compared to the mice inoculated with C. tropicalis alone and (D) one gene downregulated and two genes upregulated compared to the mice inoculated with C. albicans alone. Fold-change > ±1.5, p < 0.05.