Table 1.
Studies based on the use of BV in various skin diseases.
| Nr. | Skin Diseases | Bee Venom | ||
|---|---|---|---|---|
| Human Studies | Anial Studies | In Vitro Studies | ||
| 1. | Atopic dermatitis (DA) | Double-blind, randomized, multicentre study with q36 patients [83] | Mouse models with 1-chloro-2,4-dinitrobenzene-induced DA [75,79] Mice models with ovalbumin-induced DA [76,78] Mice models with 48/80-induced DA symptoms [80] Mice models with DA induced by Dermatophagoides farinae extract [82] |
TNF-α/IFN-γ stimulated human keratinocytes [75] TNF-α/IFN-γ stimulated human keratinocytes [77] |
| 2. | Acne | Double-blind, controlled study of 12 patients [92] Prospective, non-comparative study with 30 subjects [93] |
Intradermal injection of P. acnes into mouse ears to cause inflammation [88,91] | Production of inflammatory cytokines (IL-8) and tumor necrosis (TNF-α) was examined in THP-1 cells [87] Effect of melittin on inflammatory cytokine production in heat-destroyed P.acnes-treated keratinocytes [88] |
| 3. | Psoriasis | 48 patients, randomized to four different treatment groups [96] Randomized double-blind study with 50 patients [97] |
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| 4. | Wound | Mice models with dorsal wounds [102] Type I diabetic mouse models with diabetic wounds [103,105] Diabetic rat models with wounds [104] |
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| 5. | Alopecia | Dorsal skin of female C57BL/6 mice [111] BV-treated, adipose-derived stem cells were injected subcutaneously into mice [112] |
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| 6. | Wrinkles | Clinical study with 22 female volunteers [117] | Assessment of skin sensitization to BV in guinea pigs and rats [116] | |
| 7. | Melanoma | There are no human studies at present | Perfluorocarbon nanoparticles loaded with melittin for mouse melanoma B16F10 [123] | B16F10, A375SM, and SKMEL28 melanoma cells [121] Human melanoma cells A2058 [122] |
| 8. | Morphea | Clinical study; patients of 64 years; acupuncture [125] | ||
| 9. | Vitiligo | Human melanocytes [127] Guinea pig skins grown in organs [129] |
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| 10. | Fungal infection | Forty-eight plates inoculated with Trichophyton rubrum [51] Ten clinical isolates of C. albicans that were cultured from blood and vagina via the disc diffusion method [131] |
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