Table 5.
Genotype distribution and allele frequencies of three selected SNPs of genes of TNFα, IL-6 and IL-10 in mothers with extremely early PTB and respective controls in specific inheritance models.
| SNP/Inheritance Model | Genotype [n (%)] | OR (95% CI) |
p * | ||
|---|---|---|---|---|---|
| Term Birth (n = 200) |
Extremely Early PTB (n = 16) |
||||
| TNFα (rs1800629) | G/G | 154 (77) | 13 (81.2) | 1 | 0.81 |
| A/G | 44 (22) | 3 (18.8) | 0.81 (0.22–2.96) | ||
| A/A | 2 (1) | 0 | 0 (0–NA) | ||
| Allele | G | 352 (88) | 29 (91) | 1.32 (0.39–4.49) | 0.66 |
| A | 48 (12) | 3 (9) | |||
| Dominant model of inheritance | G/G | 154 (77) | 13 (81.2) | 1 | 0.69 |
| A/G–A/A | 46 (23) | 3 (18.8) | 0.77 (0.21–2.83) | ||
| Recessive model of inheritance | G/G–A/G | 198 (99) | 16 (100) | 1 | 0.58 |
| A/A | 2 (1) | 0 | 0 (0–NA) | ||
| Superdominant model of inheritance | G/G–A/A | 156 (78) | 13 (81.2) | 1 | 0.76 |
| A/G | 44 (22) | 3 (18.8) | 0.82 (0.22–3.0) | ||
| IL-10 (rs1800896) | A/A | 68 (34) | 5 (31.2) | 1 | 0.71 |
| A/G | 88 (44) | 6 (37.5) | 0.93 (0.27–3.17) | ||
| G/G | 44 (22) | 5 (31.2) | 1.55 (0.42–5.65) | ||
| Allele | A | 224 (56) | 16 (50) | 0.79 (0.38–1.62) | 0.51 |
| G | 176 (44) | 16 (50) | |||
| Dominant model of inheritance | A/A | 68 (34) | 5 (312) | 1 | 0.82 |
| A/G–G/G | 132 (66) | 11 (68.8) | 1.13 (0.38–3.39) | ||
| Recessive model of inheritance | A/A–A/G | 156 (78) | 11 (68,8) | 1 | 0.41 |
| G/G | 44 (22) | 5 (31.2) | 1.61 (0.53–4.88) | ||
| Superdominant model of inheritance | A/A–G/G | 112 (56) | 10 (62.5) | 1 | 0.61 |
| A/G | 88 (44) | 6 (37.5) | 0.76 (0.27–2.18) | ||
| IL-6 (rs1800796) | G/G | 176 (88) | 15 (93.8) | 1 | 0.73 |
| C/G | 23 (11.5) | 1 (6.2) | 0.51 (0.06–4.04) | ||
| C/C | 1 (0.5) | 0 | 0 (0–NA) | ||
| Allele | G | 375 (94) | 31 (97) | 2,07 (0.27–15.77) | 0.48 |
| C | 25 (6) | 1 (3) | |||
| Dominant model of inheritance | G/G | 176 (88) | 15 (93.8) | 1 | 0.46 |
| C/G–C/C | 24 (12) | 1 (6.2) | 0.49 (0.06–3.87) | ||
| Recessive model of inheritance | G/G–C/G | 199 (99.5) | 16 (100) | 1 | 0.69 |
| C/C | 1 (0.5) | 0 | 0 (0–NA) | ||
| Superdominant model of inheritance | G/G–C/C | 177 (88.5) | 15 (93.8) | 1 | 0.44 |
| C/G | 23 (11.5) | 1 (6.2) | 0.51 (0.06–4.07) | ||
| G/G | 176 (88) | 15 (93.8) | 1 | ||
* Chi-squared test. Abbreviations: SNP, single nucleotide polymorphism; PTB, premature birth; IL-10, interleukin 10; IL-6, interleukin 6; TNFα, tumor necrosis factor alpha; OR, odds ratio; CI, confidence interval. Bold denotes statistical significance.