Table 7.
Genotype distribution and allele frequencies of three selected SNPs of genes of TNFα, IL-6 and IL-10 in mothers with late premature birth and respective controls in specific inheritance models.
| SNP/Inheritance Models | Genotype [n (%)] | OR (95% CI) |
p * | ||
|---|---|---|---|---|---|
| Term Birth (n = 200) |
Late PTB (n = 151) |
||||
| TNFα (rs1800629) | G/G | 154 (77) | 111 (73.5) | 1 | 0.09 |
| A/G | 44 (22) | 33 (21.9) | 1.04 (0.62–1.74) | ||
| A/A | 2 (1) | 7 (4.6) | 4.86 (0.99–23.82) | ||
| Allele | G | 352 (88) | 255 (84) | 0.69 (0.45–1.07) | 0.09 |
| A | 48 (12) | 47 (16) | |||
| Dominant inheritance model | G/G | 154 (77) | 111 (73.5) | 1 | 0.45 |
| A/G–A/A | 46 (23) | 40 (26.5) | 1.21 (0.74–1.97) | ||
| Recessive inheritance model | G/G–A/G | 198 (99) | 144 (95.4) | 1 | 0.03 |
| A/A | 2 (1) | 7 (4.6) | 4.81 (0.99–23.51) | ||
| Superdominant inheritance model | G/G–A/A | 156 (78) | 118 (78.2) | 1 | 0.97 |
| A/G | 44 (22) | 33 (21.9) | 0.99 (0.59–1.65) | ||
| IL-10 (rs1800896) | A/A | 68 (34) | 45 (29.8) | 1 | 0.07 |
| A/G | 88 (44) | 84 (55.6) | 1.44 (0.89–2.33) | ||
| G/G | 44 (22) | 22 (14.6) | 0.76 (0.40–1.43) | ||
| Allele | A | 224 (56) | 174 (58) | 1.07 (0.79–1.44) | 0.67 |
| G | 176 (44) | 128 (42) | |||
| Dominant inheritance model | A/A | 68 (34) | 45 (29.8) | 1 | 0.40 |
| A/G–G/G | 132 (66) | 106 (70.2) | 1.21 (0.77–1.91) | ||
| Recessive inheritance model | A/A–A/G | 156 (78) | 129 (85.4) | 1 | 0.08 |
| G/G | 44 (22) | 22 (14.6) | 0.60 (0.34–1.06) | ||
| Superdominant inheritance model | A/A–G/G | 112 (56) | 67 (44.4) | 1 | 0.03 |
| A/G | 88 (44) | 84 (55.6) | 1.60 (1.04–2.44) | ||
| IL-6 (rs1800796) | G/G | 176 (88) | 133 (88.1) | 1 | 0.98 |
| C/G | 23 (11.5) | 17 (11.3) | 0.98 (0.50–1.90) | ||
| C/C | 1 (0.5) | 1 (0.7) | 1.32 (0.08–21.35) | ||
| Allele | G | 375 (94) | 283 (94) | 0.99 (0.54–1.84) | 0.98 |
| C | 25 (6) | 19 (6) | |||
| Dominant inheritance model | G/G | 176 (88) | 133 (88.1) | 1 | 0.98 |
| C/G–C/C | 24 (12) | 18 (11.9) | 0.99 (0.52–1.90) | ||
| Recessive inheritance model | G/G–C/G | 199 (99.5) | 150 (99.3) | 1 | 0.84 |
| C/C | 1 (0.5) | 1 (0.7) | 1.33 (0.08–21.38) | ||
| Superdominant inheritance model | G/G–C/C | 177 (88.5) | 134 (88.7) | 1 | 0.94 |
| C/G | 23 (11.5) | 17 (11.3) | 0.98 (0.50–1.90) | ||
* Chi-squared test. Abbreviations: SNP, single nucleotide polymorphism; PTB, premature birth; IL-10, interleukin 10; IL-6, interleukin 6; TNFα, tumor necrosis factor alpha; OR, odds ratio; CI, confidence interval. Bold denotes statistical significance.