Table 8.
Frequency of haplotypes of three SNPs and their possible association with PTB in probands.
| Haplotype | n (%) | OR (95%CI) | χ2 | p * | adjp † | |||
|---|---|---|---|---|---|---|---|---|
| PTB | Term Birth | |||||||
| Mothers | χ2 = 2.41 df = 4 p = 0.66 |
|||||||
| rs1800629 | rs1800896 | rs1800796 | ||||||
| G | G | G | 117 (29.3) | 134 (33.5) | 0.83 (0.61–1.11) | 1.56 | 0.22 | 0.42 |
| G | A | G | 210 (52.7) | 199 (49.7) | 1.13 (0.85–1.49) | 0.73 | 0.21 | 0.55 |
| A | G | G | 29 (7.2) | 25 (6.2) | 1.18 (0.68–2.05) | 0.34 | 0.56 | 0.64 |
| A | A | G | 18 (4.5) | 17 (4.2) | 1.07 (0.54–2.10) | 0.67 | 0.41 | 0.85 |
| G | G | C | 10 (2.5) | 14 (3.5) | 0.71 (0.31–1.62) | 0.04 | 0.85 | 0.85 |
Abbreviations: PTB, premature birth; OR odds ratio; CI, confidence interval. Bold denotes statistical significance. † Correction of p value by Benjamini–Hochberg method. * Chi-squared test.