TABLE 3.

Host range and cell tropism of PERV-A, PERV-B, and PERV-C envelopes

Species	Cell	Titer (U/ml) of lacZ pseudotypea
		PERV-A	PERV-B	PERV-C
Pig	PK15	<4	2,100b	1,550
	ST-IOWA	30,000	940	3,700
	PAE	6	<2	<2
	MPK	164	<4	<4
Human	293	12,000	3,800	<2
	TE671	5,800	320	<2
	HeLa	24,000	420	<2
	HT1080-1	82	290	890
	HT1080-2	16	350	10
	FLYRD18	48	25	12
	HOS	<2	<2	<2
	U87	830	120	<2
	MRC-5	150	<2	<2
	SupT1	<2	2	<2
	Raji	2	200	<2
	Molt-4	2	2	<2
Nonhuman primates
African green monkey	Vero	<2	<2	<2
	COS-7	<2	<2	<2
Rhesus	FRhK	<2	<2	<2
Cynomolgus	CynomK1	<2	<2	NT
Baboon	26CB1	<2	<2	<2
Chimpanzee	CP132	<2	<2	NT
Mink	Mv-1-Lu	7,800	5,600	<2
Mouse	NIH 3T3	<4	2,100	<2
	M. dunni	<4	2,100	<2
Rat	NRK	<4	9,600	<2
	HSN	<4	12,400	<2
Hamster	CHO	32	<2	<2
	BHK	<2	<2	<2
Rabbit	SIRC	<4	1,380	<2
Bat	Tb-1-Lu	<2	14	<2
Dog	Th2CfS+L−	<2	<2	<2
	D17	760	<2	<2
Cat	CCCS+L−	190	<2	<2

^aAverages of duplicate titers of lacZ pseudotypes are shown. Errors were less than 30% of the values. All cultures except hamster cells were sensitive to control pseudotypes, lacZ(RD114), lacZ(GALV), or lacZ(MLV-A). BHK and CHO cells could be transduced by lacZ(MLV-E) after tunicamycin treatment. NT, not tested. 

^bPK15 cells were resistant to lacZ(PERV-B) in an earlier, preliminary experiment.