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. 2024 Apr 26;4(4):e0003078. doi: 10.1371/journal.pgph.0003078

Table 4. Likelihood of incurring catastrophic cost using HCA1 method of indirect cost calculation.

General population (N = 528) Urban slum dwellers (N = 526) Tea garden families (N = 403) All participants (N = 1457)
Explanatory variables Adjusted OR (95% CI) p-value Adjusted OR (95% CI) p-value Adjusted OR (95% CI) p-value Adjusted OR (95% CI) p-value
Age (in years) 1.01 (0.99, 1.03) 0.18 1.01 (0.99, 1.03) 0.22 1.01 (1.00, 1.03) 0.28 1.01 (1.00, 1.02) 0.05
Sex
Male (Reference) 1.00 1.00 1.00 1.00
Female 1.06 (0.66, 1.70) 0.80 1.59 (0.91, 2.77) 0.10 1.34 (0.85, 2.12) 0.21 1.34 (1.02, 1.76) 0.04
Education
Up to primary education (Reference) 1.00 1.00 1.00 1.00
Secondary education 0.99 (0.59, 1.67) 0.98 0.63 (0.34, 1.16) 0.13 1.19 (0.64, 2.20) 0.58 0.80 (0.58, 1.10) 0.17
Higher secondary education and above 0.48 (0.26, 0.88) 0.02 0.62 (0.28, 1.37) 0.23 0.57 (0.22, 1.48) 0.24 0.61 (0.40, 0.91) 0.02
Pre-TB annual household income (Indian Rupee)
Less than 100,000 (Reference) 1.00 1.00 1.00 1.00
100,000 –less than 200,000 0.13 (0.07, 0.23) <0.001 0.14 (0.08, 0.27) <0.001 0.19 (0.11, 0.31) <0.001 0.16 (0.11, 0.21) <0.001
200,000 and above 0.06 (0.03, 0.12) <0.001 0.03 (0.01, 0.06) <0.001 --- 0.07 (0.05, 0.11) <0.001
Health insurance
Having health insurance (Reference) 1.00 1.00 1.00 1.00
Not having health insurance 1.44 (0.88, 2.34) 0.15 1.03 (0.53, 1.99) 0.93 0.97 (0.60, 1.58) 0.91 1.11 (0.83, 1.50) 0.48
Type of TB
Pulmonary TB (Reference) 1.00 1.00 1.00 1.00
Extrapulmonary TB 1.54 (0.95, 2.50) 0.08 2.21 (1.23, 3.98) 0.01 1.21 (0.72, 2.03) 0.48 1.68 (1.25, 2.26) <0.001
Delay from symptom initiation to treatment 1.01 (0.99, 1.03) 0.41 1.01 (0.98, 1.04) 0.625 1.01 (0.98, 1.04) 0.44 1.01 (1.00, 1.03) 0.08
Direct cost of TB treatment (Log cost) * 2.88 (2.22, 3.74) <0.001 7.37 (4.85, 11.21) <0.001 1.70 (1.41, 2.05) <0.001 2.66 (2.30, 3.06) <0.001
Residential status
Urban (Reference) 1.00 --- --- 1.00
Rural 0.90 (0.57, 1.42) 0.66 1.27 (0.95, 1.70) 0.11
Wealth quintile
Poorest (Reference) --- --- --- 1.00
Poorer 0.68 (0.45, 1.02) 0.06
Middle 0.64 (0.42, 0.96) 0.03
Richer 0.71 (0.47, 1.08) 0.11
Richest 0.55 (0.35, 0.88) 0.01
Adjusted R2 ** 0.31 0.41 0.19 0.29

Notes: HCA1: Human capital approach where hours spent was calculated using minimum wage rate for all and household income as denominator; OR: Odds Ratio; CI: Confidence Interval; Blanks indicate Not Applicable;

* One patient among general population and 24 patients among tea garden families did not incur any direct cost, hence, were excluded from this analysis;

**Cox and Snell R2