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. 2024 Apr 16;20(4):e1012141. doi: 10.1371/journal.ppat.1012141

Fig 2. KSHV ORF55 has a critical role in progeny virion production.

Fig 2

(A-B) SLK.iBAC or SLK.iBACΔORF55 cells were induced with Dox (1 μg/mL) and sodium butyrate (0.5 mM) for 48 h, and WCLs were analyzed by immunoblotting (A). The supernatants were collected, and KSHV infectious units were quantified (B). (C-F) SLK.iBAC or SLK.iBACΔORF55 cells were induced as described in Fig 2A. Viral gene expression was quantified by RT-qPCR (C), and WCLs were analyzed by immunoblotting (D). The intracellular (E) and extracellular (F) viral genome copy number of KSHV-WT or KSHV-ΔORF55 were quantified by qPCR.