Table 3.
Risk factors for overall 30-day case fatality rate in patients with septic shock by univariate and multivariate analysis.
| Characteristics | Univariate Adjusted OR (95% CI) |
Univariate p-Value |
Adjusted OR (95% CI) |
Multivariate p-Value |
|---|---|---|---|---|
| Mechanical ventilation | 9.67 (5.35–17.48) | <0.001 | 9.00 (4.72–17.18) | <0.001 |
| β-lactam + aminoglycoside | 0.26 (0.16–0.42) | <0.001 | 0.58 (0.32–1.05) | 0.072 |
| MDRPA a | 3.27 (1.87–5.70) | <0.001 | 1.98 (1.00–3.90) | 0.048 |
| Age | 1.00 (0.98–1.01) | 0.653 | 1.02 (1.00–1.03) | 0.109 |
| Sex | 1.04 (0.65–1.66) | 0.874 | 1.25 (0.71–2.22) | 0.443 |
| High risk MASCC index score b | 0.99 (0.41–2.42) | 0.989 | 0.86 (0.28–2.59) | 0.782 |
| IEAT c | 4.49 (2.08–10.00) | <0.001 | 2.47 (1.01–5.88) | 0.047 |
| Persistent bloodstream infection | 2.54 (1.25–5.15) | 0.010 | 2.49 (1.12–5.56) | 0.026 |
| Granulocyte colony-stimulating factor | 0.43 (0.27–0.68) | <0.001 | 0.33 (0.19–0.58) | <0.001 |
| Pneumonia | 1.29 (0.81–2.04) | 0.286 | 0.84 (0.39–1.82) | 0.652 |
| Urinary tract infection | 0.33 (0.13–0.86) | 0.023 | 0.27 (0.07–0.99) | 0.047 |
| Endogenous source | 0.70 (0.44–1.13) | 0.143 | 0.46 (0.20–1.03) | 0.058 |
| Catheter infection | 1.16 (0.51–2.64) | 0.728 | 0.65 (0.21–2.05) | 0.466 |
a MDRPA: multidrug-resistant Pseudomonas aeruginosa; b MASCC: Multinational Association for Supportive Care in Cancer; c IEAT: inadequate empirical antibiotic therapy.