Figure 4.

Schematic representation of perceptive evaluation of passive gastrointestinal absorption and Bbain penetration with BEA in the WLOGP-versus-TPSA using BOILED-Egg. The white region is for high probability of passive absorption by the gastrointestinal tract, and the yellow region (yolk) is for high probability of brain penetration. Yolk and white areas are not mutually exclusive. In addition, the points are colored in blue if predicted as actively effluxed by P-gp (PGP+) and in red if predicted as non-substrate of P-gp (PGP−).