Table 1.
Characteristics of the included studies.
| Author | Year | Type | Main Outcome | Country | Patient (n) | Cervical Cancer > 2 cm, n (% of total) | Age (Median) |
|---|---|---|---|---|---|---|---|
| Cao et al. [16] | 2013 | Prospective case-control | To compare the surgical and pathologic characteristics, the prognosis, and fertility outcomes of the patients treated by VRT or ART |
China | 150 | 48 (32) | 30.0 (18–39) |
| De Vincenzo et al. [17] | 2021 | Prospective observational | To evaluate the feasibility of NACT followed by CKC in patients with 2018 FIGO stage IB2–IIA1 cervical cancer who desired to maintain fertility | Italy | 13 | 9 (69.2) | 29 (23–36) |
| Deng et al. [18] | 2016 | Retrospective observational | To evaluate the safety of SLNB-guided ART by observing surgical, oncologic, and fertility outcomes in patients who wished to preserve their fertility | China | 45 | 45 (100) | 28.5 (19–40) |
| Guo et al. [19] | 2018 | Retrospective observational | To compare the surgical and oncologic outcomes between ART and RH for stage IA2–IB1 cervical cancer | China | 329 | 75 (22.8) | 31 (18–42) |
| Lanowska et al. [20] | 2013 | Retrospective observational | To assess the oncologic and fertility outcomes of treatment in patients with cervical cancer of more than 2 cm seeking parenthood | Germany | 20 | 20 (100) | 32 (26–41) |
| Li et al. [6] | 2013 | Retrospective observational | To report the surgical and oncological safety of ART for selected patients with cervical cancer ≥2 cm in size | China | 133 | 62 (46.6) | 30.4 (20–44) |
| Lintner et al. [21] | 2013 | Retrospective observational | To report ART experience in patients with a cervical cancer more than 2 cm in diameter | Hungary | 45 | 45 (100) | 32 (24–43) |
| Lu et al. [22] | 2014 | Retrospective observational | To support the feasibility and safety of intra-arterial NACT followed by total laparoscopic radical trachelectomy in stage IB1 cervical cancer with a tumor larger than 2 cm | China | 7 | 7 (100) | 28 (22–35) |
| Marchiolè et al. [23] | 2018 | Retrospective observational | To assess the oncological and reproductive outcomes of patients with early-stage large cervical cancers (2–5 cm) undergoing FST | France | 19 | 19 (100) | 28.3 (21–37) |
| Plante et al. [24] | 2006 | Case series | To present the cases of 3 young women with bulky stage IB1 cervical cancer treated with NACT followed by laparoscopic pelvic node dissection and VRT | Canada | 3 | 3 (100) | 35 (26–36) |
| Rendòn et al. [25] | 2020 | Retrospective observational | To report on the oncological and obstetrical outcomes of NACT followed by FST in patients diagnosed with cervical cancer ≥2 cm | Colombia | 25 | 25 (100) | 27 (20–37) |
| Robova et al. [26] | 2014 | Prospective observational | To assess oncological and pregnancy outcomes after high-dose density NACT and FST in cervical cancer | Czech Republic | 28 | 28 (100) | 28.6 (15–34) |
| Salihi et al. [27] | 2015 | Retrospective observational | To discuss the cases of 11 patients with cervical carcinoma stage IB treated with NACT followed by large cone resection | Belgium | 10 | 5 (50) | 31.7 (25–36) |
| Tesfai et al. [28] | 2015 | Retrospective observational | To assess the feasibility, safety, oncological, and obstetric outcomes in patients with cervical tumors >2 cm treated with NACT in preparation for ART | Netherlands | 19 | 19 (100) | 28 (19–36) |
| Vercellino et al. [29] | 2012 | Prospective observational | To assess the results of treatment of women with stage I cervical cancer >2 cm in diameter seeking fertility preservation | Germany | 18 | 6 (33.3) | 31.3 (25–38) |
| Wethington et al. [8] | 2016 | Retrospective observational | To report the author’s trachelectomy experience with cervical tumors measuring 2–4 cm | United States | 29 | 9 (31) | 31 (22–40) |
| Zusterzeel et al. [30] | 2020 | Retrospective observational | To evaluate the oncological and fertility outcomes of treatment in patients receiving an FST consisting of NACT followed by VRT | Netherlands | 18 | 14 (77.8) | 29 (23–36) |
VRT: vaginal radical trachelectomy; ART: abdominal radical trachelectomy; NACT: neo-adjuvant chemotherapy; CKC: cold-knife conization; SLNB: sentinel lymph node biopsy; RH: radical hysterectomy; FST: fertility-sparing treatment.