Figure 3.

Overview of the proposed mechanisms of statin therapy for NASH. The arrows pointing up indicate upregulation and the pointing down indicate downregulation. IPA, indolepropionic acid; TCA, taurocholic acid; LCA, lithocholic acid; DCA, deoxycholic acid; GPX4, glutathione peroxidase 4; PPAR, peroxisome proliferator-activated receptor; AMPK, AMP-activated protein kinase; HSC, hepatic stellate cell; KC, Kupffer cells; LSEC, liver sinusoidal endothelial cells; PON1, paraoxonase 1; GTPase, small guanine triphosphate binding proteins; NPC, non-parenchymal cell.