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. 2024 Apr 11;14(4):214. doi: 10.3390/metabo14040214

Figure 2.

Figure 2

Figure 2

Metabolic pathway analysis using MetaboAnalyst 6.0 (A) KEGG pathway analysis of 109 annotated metabolites; the node depicts the p-value of the analyzed pathways, and the node radius shows the impact of the pathways. (B) Histogram representation of KEGG enrichment analysis of the 109 annotated metabolites. (C) Venn diagram demonstrates the identified 3624 metabolites from the LC-MS/MS analysis, out of which 109 were annotated with the NIST and MS-DIAL library; setting the significance criteria at p-value < 0.05, eight significant metabolites were obtained, with four metabolites upregulated by the fold change >1.5, one metabolite downregulated by the fold change <0.8, and 1-methylnicotinamide was selected for further analysis with an upregulated fold change of 1.62.