Fig. 5.

The significant clonal expansion of shared TCR clones among lesions of the same patient in the MPLC cohort. Schematic diagram of the shared TCR (A). The significant differences between the ratio and frequency of shared TCR clones in patients with double primary lung cancer lesions (B) and in patients with more than two lesions (C). The specific distributions of the ratio and frequency of shared TCR clones in patients with more than two lesions (D). The different colors indicate different degrees of shared TCR clones in each patient. MPLC, multiple primary lung cancer; TCR, T cell receptor. *P < 0.05, **P < 0.01, ***P < 0.001 (paired t test)