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. 2023 Dec 12;20(4):353–370. doi: 10.1007/s12519-023-00764-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Superiority and non-inferiority hypothesis testing of cellular immunogenicity against wild-type SARS-CoV-2 post-dose 2 and post-dose 3 of vaccination in the evaluable analysis population. Adolescents receiving 2 doses of CoronaVac administered intramuscularly (IM-CC) or intradermally (ID-CC) (a) and 3 doses of CoronaVac administered intramuscularly (IM-CCC) or intradermally (ID-CCC) (b) were tested for T-cell responses by flow-cytometry-based intracellular cytokine staining assays specific to S, N and M post-dose 2 or post-dose 3. The results of SNM-specific T-cell responses were calculated from the sum of responses of the individual S, N and M peptide pools. Dots and error bars show GMR estimates and two-sided 95% CI, respectively. GMR geometric mean ratio, SNM sum of individual S, N, and M peptide pools, S spike protein, N nucleocapsid protein, M membrane protein, IFN-γ interferon-γ, IL-2 interleukin-2, ID intradermal, IM intramuscular, CI confidence interval