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. 2024 Apr 26;15:3567. doi: 10.1038/s41467-024-47933-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Representative histological staining of the 8 PCW fresh frozen human eye section. Four sections from the same eye sample were processed for ST analyses. B, C Spatial localisation of the 12 clusters identified from the ST analysis. Highly expressed markers for each cluster are shown in Supplementary Data 3. D UMAP of spatial transcriptomics scRNA-Seq data. E Subclustering of ciliary margin zone (cluster 4) reveals the presence of two subclusters namely RPCs and ciliary body, and iris pigmented epithelial cells: their spatial localisation is shown in panel (F). G and (I) Expression violin plots showing the highest aggregate expression scores for early RPCs in the peripheral retina (CMZ) and late RPCs in the central retina respectively, compared to all other retinal clusters identified in the ST analysis. H and (J) Early and late RPC gene expression signatures superimposed on the spatial image of 8 PCW human eye.