Fig. 2. Manhattan plot showing common variants in the ET meta-analysis.

The -log₁₀P-values (y-axis) are plotted for each variant against their chromosomal position (x-axis). Variants with P-values below their weighted variant-class threshold are highlighted. Novel variants are marked in orange and previously reported variants are marked in blue. P-values are two-sided and derived from a likelihood-ratio test. Manhattan plots for each dataset are shown in Supplementary Fig. 2.