Table 2.
Independent association signals with a single CCV
| Fine-mapping region | SNP | Chr | Position | Alleles | AF | OR (95% CI) | P valuea | Putative target gene(s)b |
|---|---|---|---|---|---|---|---|---|
| European-specific analysis | ||||||||
| region_45 | rs116000952 | 6 | 32541270 | T/G | 0.843 | 0.92 (0.89–0.96) | 5.74E−06 | – |
| region_45 | rs6920820 | 6 | 30969938 | C/G | 0.980 | 0.84 (0.79–0.90) | 6.87E−08 | LINC00243 |
| region_61 | rs72681666 | 8 | 117641754 | T/C | 0.043 | 1.09 (1.05–1.13) | 1.57E−05 | – |
| region_62 | rs77569096 | 8 | 128468955 | A/G | 0.763 | 0.92 (0.90–0.94) | 2.06E−15 | – |
| region_84 | rs3217810 | 12 | 4388271 | T/C | 0.127 | 1.13 (1.11–1.16) | 1.96E−26 | – |
| region_108 | rs144674978 | 15 | 33149751 | T/C | 0.013 | 1.34 (1.25–1.43) | 1.11E−18 | – |
| region_133 | rs149942633 | 20 | 48983073 | T/C | 0.153 | 1.12 (1.08–1.16) | 1.93E−08 | – |
| Trans-ancestry analysis | ||||||||
| region_1 | rs112191583 | 1 | 22554378 | T/C | 0.974 | 0.88 (0.83–0.92) | 1.19E−07 | – |
| region_24 | rs704417 | 3 | 64252424 | T/C | 0.546 | 1.05 (1.03–1.06) | 4.35E−10 | – |
| region_27 | rs113569514 | 3 | 133748789 | T/C | 0.763 | 1.08 (1.07–1.10) | 1.92E−21 | SLCO2A1 |
| region_29 | rs2578155 | 4 | 94836291 | C/G | 0.503 | 1.04 (1.03–1.06) | 1.09E−09 | – |
| region_42 | rs9379084 | 6 | 7231843 | A/G | 0.144 | 0.93 (0.91–0.95) | 2.39E−12 | RREB1 |
| region_46 | rs16878812 | 6 | 35569562 | A/G | 0.892 | 1.09 (1.07–1.12) | 7.62E−15 | FKBP5 |
| region_48 | rs6933790 | 6 | 41672769 | T/C | 0.788 | 1.08 (1.06–1.10) | 2.66E−20 | – |
| region_61 | rs4129064 | 8 | 117735666 | T/G | 0.734 | 1.06 (1.04–1.07) | 1.01E−09 | – |
| region_62 | rs6983267 | 8 | 128413305 | T/G | 0.508 | 0.86 (0.85–0.87) | 1.65E−122 | MYC |
| region_72 | rs704017 | 10 | 80819132 | A/G | 0.473 | 0.92 (0.91–0.93) | 1.97E−38 | – |
| region_84 | rs12818766 | 12 | 4376091 | A/G | 0.215 | 1.10 (1.08–1.12) | 1.81E−29 | – |
| region_89 | rs7398375 | 12 | 57540848 | C/G | 0.651 | 1.07 (1.05–1.09) | 3.70E−19 | LRP1 |
| region_94 | rs11067228 | 12 | 115094260 | A/G | 0.560 | 0.95 (0.94–0.97) | 2.50E−13 | – |
| region_96 | rs116964464 | 13 | 27543193 | T/C | 0.035 | 1.11 (1.07–1.15) | 4.83E−09 | USP12 |
| region_99 | rs7325844 | 13 | 73625133 | A/G | 0.639 | 1.05 (1.04–1.07) | 1.28E−12 | – |
| region_104 | rs35107139 | 14 | 54419106 | A/C | 0.550 | 0.92 (0.91–0.93) | 4.22E−36 | – |
| region_105 | rs8020436 | 14 | 59208437 | A/G | 0.370 | 1.06 (1.05–1.08) | 1.27E−17 | – |
| region_108 | rs17816465 | 15 | 33156386 | A/G | 0.193 | 1.09 (1.07–1.10) | 5.73E−20 | – |
| region_116 | rs1078643 | 17 | 10707241 | A/G | 0.765 | 1.09 (1.07–1.11) | 2.31E−27 | – |
| region_132 | rs6066825 | 20 | 47340117 | A/G | 0.662 | 1.08 (1.07–1.10) | 2.13E−32 | – |
| region_136 | rs1741640 | 20 | 60932414 | T/C | 0.208 | 0.88 (0.86–0.89) | 8.15E−55 | LAMA5, CABLES2 |
Chr and Position GRCh37, Alleles risk allele/Reference allele, AF Allele frequency, OR odds ratio, CI confidence interval. aP value derived from trans-ancestry or European-ancestry meta-analysis under the fixed-effects inverse variance weighted model; b”-“ – No target genes were prioritized for the variant in this study.