Table 3.

The 56 CRC susceptibility gene candidates not previously reported

Fine-mapping region	Gene	Lead variant	Distal	Proximal	Coding	Colocalization (eQTL)	Colocalization (mQTL)
region_1	CELA3B	rs11579545				+
region_1	HSPG2	rs11579545	+			+	+
region_5	PTGER3	rs2651244				+
region_7	TNFSF18	rs10489274					+
region_9	LGR6	rs12122827					+
region_10	CNTN2	rs12078075		+			+
region_12	FMN2	rs2078095				+
region_14	PPP1R21	rs77272589		+		+
region_16	LCT	rs1446585					+
region_21	GOLGA4	rs1800734				+
region_21	MLH1	rs1800734		+		+
region_24	ADAMTS9	rs6445418					+
region_24	PRICKLE2	rs704417				+
region_27	SLCO2A1	rs113569514		+
region_28	LRRC34	rs10936599			+
region_28	ACTRT3	rs10936599	+	+
region_28	MYNN	rs10936599	+		+
region_34	HPGD	rs1426947				+
region_42	LY86	rs1294438					+
region_44	OR2I1P	rs73402748				+
region_46	SRPK1	rs16878812				+
region_49	RUNX2	rs57939401					+
region_55	IGFBP3	rs80077929					+
region_62	MYC	rs4733655, rs6983267	+
region_63	CDKN2B	rs7859362	+
region_63	MTAP	rs7859362	+
region_68	VAV2	rs7038489					+
region_73	KIF20B	rs140356782				+
region_73	PANK1	rs140356782				+	+
region_74	GOT1	rs117746067		+
region_75	BORCS7	rs12268849				+
region_75	AS3MT	rs12268849		+		+
region_79	ANO1	rs10751097					+
region_92	NTN4	rs11108175					+
region_93	CUX2	rs3858704					+
region_94	TBX3	rs7300312, rs11067228	+				+
region_96	USP12	rs116964464	+
region_101	IRS2	rs1078563				+
region_101	COL4A2	rs4773184					+
region_107	BCL11B	rs80158569				+
region_108	GOLGA8N	rs56338436				+
region_110	SENP8	rs8031386		+			+
region_111	CIB1	rs12913420		+		+
region_111	ZNF774	rs7179095	+
region_119	MYL12A	rs1612128	+
region_119	MYL12B	rs1612128	+
region_119	TGIF1	rs1612128	+
region_125	B3GNT8	rs1963413				+
region_133	CEBPB	rs1971480	+
region_134	RBM38	rs34161672	+
region_134	BMP7	rs6014965	+				+
region_138	LSS	rs9983528				+	+
region_138	PCNT	rs9983528			+	+
region_138	SPATC1L	rs9983528				+	+
region_142	WNT7B	rs62228060					+
region_142	ATXN10	rs78106213				+

The lead variant for each gene is presented by independent association signals. Supporting evidence for the likely target gene is presented as follows: “Distal”—the CCV(s) located in distal enhancer elements of the gene; “Proxmial”—the CCV(s) located in proximal promoter element of the gene; “Coding”—the CCV is potential loss-of-function variants of the gene; “Colocalization (eQTL)”—target genes identified from eQTL colocalization analysis; “Colocalization (mQTL)”—target genes identified from mQTL colocalization analysis. “+” indicates the presense of supportive evidence.