Table 4.

The 80 previously reported CRC susceptibility genes supported in this study

Fine-mapping region	Gene	Lead variant	Distal	Proximal	Coding	Colocalization (eQTL)	Colocalization (mQTL)
region_1	WNT4	rs6426749				+
region_2	FHL3	rs61776719				+	+
region_8	LAMC1	rs8179460	+	+
region_9	LMOD1	rs12137232	+			+
region_15	ACTR1B	rs11692435			+	+
region_18	STK39	rs4668039	+			+	+
region_20	TMBIM1	rs3731861	+	+	+	+
region_23	SFMBT1	rs2001732, rs2581817				+	+
region_26	BOC	rs73235124		+
region_30	TET2	rs2047409, rs902443				+	+
region_31	UGT8	rs3924508		+
region_35	TERT	rs2735940					+
region_40	CDX1	rs2302275		+
region_41	ERGIC1	rs472959					+
region_42	RREB1	rs9379084			+
region_43	EDN1	rs2070699					+
region_43	HIVEP1	rs4714081				+	+
region_47	CDKN1A	rs9470361					+
region_48	TFEB	rs6933790				+
region_52	DCBLD1	rs6911915				+
region_53	TCF21	rs151127921	+
region_54	GNA12	rs1182197			+	+	+
region_55	TBRG4	rs67681615					+
region_55	TNS3	rs6948177	+
region_56	ABHD11	rs7806956				+	+
region_57	TRIM4	rs2527927		+		+
region_62	POU5F1B	rs6983267				+
region_64	DCAF12	rs11557154			+
region_68	BRD3	rs11789898				+	+
region_70	BAMBI	rs1773860	+
region_71	ASAH2B	rs10740013				+
region_72	ZMIZ1	rs704017					+
region_74	ENTPD7	rs35564340				+
region_76	TCF7L2	rs4554812	+
region_78	TMEM258	rs174570		+
region_81	TRPC6	rs2186607				+
region_82	ARHGAP20	rs3087967				+
region_82	FDX1	rs3087967				+
region_83	BCL9L	rs497916	+
region_85	PLEKHG6	rs10849434, rs1003563	+	+			+
region_88	CERS5	rs11169572					+
region_88	ATF1	rs11169572		+			+
region_88	DIP2B	rs11169572				+	+
region_89	LRP1	rs7398375	+			+	+
region_91	TSPAN8	rs11178634			+	+
region_98	SMAD9	rs12427846		+		+	+
region_99	KLF5	rs1304959, rs78341008	+
region_102	NIN	rs1042266				+
region_102	ABHD12B	rs1042266				+	+
region_102	PYGL	rs1042266				+	+
region_103	NID2	rs1151580				+	+
region_104	BMP4	rs1957628, rs35107139	+				+
region_105	DACT1	rs8020436				+	+
region_108	GREM1	rs16970016					+
region_109	SMAD6	rs3809570		+			+
region_109	SMAD3	rs56324967	+
region_112	ZFP90	rs9924886				+
region_112	CDH1	rs9924886	+	+			+
region_115	NXN	rs11247566					+
region_117	SOX9	rs112592783	+
region_118	METRNL	rs35204860				+	+
region_120	SMAD7	rs4939821, rs2337113	+				+
region_122	FUT3	rs10409772			+	+
region_124	RHPN2	rs28840750	+			+
region_126	FUT2	rs12460535			+	+
region_127	TRIM28	rs11670192				+
region_127	ZNF584	rs8099852, rs11670192		+		+
region_128	BMP2	rs990999				+
region_130	MAP1LC3A	rs6059938				+
region_130	MYH7B	rs6059938			+
region_131	TOX2	rs6073241				+	+
region_132	PREX1	rs6066825					+
region_133	PARD6B	rs6091213				+
region_133	PTPN1	rs6091213	+
region_135	GNAS	rs8121252		+
region_136	RBBP8NL	rs1741640				+
region_137	STMN3	rs6089763					+
region_139	ZNRF3	rs4616575	+			+
region_140	PDGFB	rs130651					+
region_142	RIBC2	rs6007600				+	+

The lead variant for each gene is presented by independent association signals. Supporting evidence for the likely target gene is presented as follows: “Distal”—the CCV(s) located in distal enhancer elements of the gene; “Proxmial”—the CCV(s) located in proximal promoter element of the gene; “Coding”—the CCV is potential loss-of-function variants of the gene; “Colocalization (eQTL)”—target genes identified from eQTL colocalization analysis; “Colocalization (mQTL)”—target genes identified from mQTL colocalization analysis. “+” indicates the presense of supportive evidence.