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. 2024 Apr 6;32(2):200799. doi: 10.1016/j.omton.2024.200799

Figure 2.

Figure 2

Virus replication and cytotoxicity in glioblastoma cells

(A) Glioblastoma cells (A172, D54, U138, U87, and D458) were exposed to 0.1 PFU of HSV-1(F), R3616, or C5252 per cell. Virus progeny were collected at 48 hpi and titrated using Vero cells. (B) Similar to (A) but cells were exposed to 1.0 PFU per cell. (C) Glioblastoma cells were infected with HSV-1(F), R3616, or C5252 at 0.1 PFU per cell, and cytotoxicity was assessed via CCK8 assay at 48 hpi. (D) Similar to (C) but cells exposed to 1.0 PFU per cell. Data represent mean ± SD; N.S. p > 0.05, ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. Student’s t test (two-tailed) was used for statistical analysis.