Table 2.
Univariate and multivariate Cox regression model for factors associated with independent predictors of cancer-specific survival in patients underwent radical cystectomy.
| Variable | Univariate |
Multivariate |
||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age, 10 yearsa | 1.18 (1.05–1.33) | 0.005 | – | –b |
| TTC, week | 1.08 (1.06–1.09) | <0.001 | 1.07 (1.05–1.08) | <0.001 |
| Anemia | ||||
| No | Reference | – | – | – |
| Yes | 1.33 (1.10–1.62) | 0.004 | – | –b |
| PBT | 0.001 | |||
| No | Reference | – | – | |
| One | 1.48 (1.09–2.00) | 0.01 | 1.40 (1.03–1.90) | 0.03 |
| Two or more | 1.82 (1.37–2.42) | <0.001 | 1.72 (1.29–2.29) | <0.001 |
| Hydronephrosis | 0.002 | |||
| No | Reference | – | – | |
| Unilateral | 1.30 (1.04–1.63) | 0.02 | 1.20 (0.95–1.51) | 0.1 |
| Bilateral | 1.73 (1.36–2.20) | <0.001 | 1.54 (1.21–1.97) | <0.001 |
| Cell type | 0.001 | |||
| UC | Reference | – | – | |
| SCC | 0.50 (0.38–0.66) | <0.001 | 0.60 (0.45–0.81) | 0.001 |
| Adeno | 1.01 (0.60–1.69) | 0.9 | 1.09 (0.64–1.84) | 0.7 |
| Others | 1.17 (0.71–1.94) | 0.5 | 1.58 (0.95–2.64) | 0.07 |
| Positive LN | ||||
| No | Reference | – | – | – |
| Yes | 2.38 (1.95–2.91) | <0.001 | 1.53 (1.21–1.95) | <0.001 |
| LVI | ||||
| No | Reference | – | – | – |
| Yes | 2.21 (1.81–2.70) | <0.001 | 1.28 (1.01–1.62) | 0.044 |
| pT | ||||
| T1-T2 | Reference | – | – | – |
| T3-T4 | 2.17 (1.78–2.66) | <0.001 | 1.77 (1.41–2.22) | <0.001 |
Adeno, adenocarcinoma; CI, confidence interval; HR, hazards ratio; LVI, lymphovascular invasion; LN, lymph node; PBT, perioperative blood transfusion number of packed red blood cells; SCC, squamous cell carcinoma; TTC, time to radical cystectomy; UC, urothelial carcinoma; pT, pathological tumor stage.
Note: univariate and multivariate analyses included only significant variables.
a
HR was calculated per every 10-year increase of age.
b
Stepwise approach excluded the non-significant variable from the final equation.