Comparison 2. Adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Haematological effects	13		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Anaemia	13	3854	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.98, 1.27]
1.2 Neutropenia	13	3855	Risk Ratio (M‐H, Fixed, 95% CI)	2.15 [1.76, 2.61]
1.3 Thrombocytopenia	10	2195	Risk Ratio (M‐H, Fixed, 95% CI)	2.63 [1.68, 4.11]
2 Fatigue and flu‐like symptoms	13		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 General fatigue	11	3608	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.96, 1.07]
2.2 Headache	6	3146	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.93, 1.07]
2.3 Rigours	4	2641	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.88, 1.08]
2.4 Arthralgia	4	2934	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [1.05, 1.35]
2.5 Myalgia	5	3087	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.90, 1.06]
2.6 Pyrexia	6	3180	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.99, 1.18]
2.7 Weight loss	6	2524	Risk Ratio (M‐H, Fixed, 95% CI)	1.17 [0.98, 1.39]
2.8 Asthenia	3	2126	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.88, 1.25]
3 Psychiatric symptoms	12		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Depression	12	3743	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.82, 1.02]
3.2 Insomnia	5	3087	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.91, 1.10]
3.3 Irritability	3	2491	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.86, 1.09]
4 Dermatological symptoms	8		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Alopecia	5	3087	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.88, 1.09]
4.2 Pruritus	5	3027	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.96, 1.25]
4.3 Skin rash	5	2740	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.93, 1.25]
4.4 Injection site reaction	4	1817	Risk Ratio (M‐H, Fixed, 95% CI)	1.71 [1.50, 1.93]
5 Thyroid malfunction	8	1222	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.73, 2.00]
6 Gastrointestinal symptoms	6		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 Decreased appetite	6	3136	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.93, 1.19]
6.2 Nausea	4	3023	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [1.01, 1.26]
6.3 Diarrhoea	3	2126	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.93, 1.41]