Table 1.
NTP In Vivo Data. The effect levels are all given in mg/kg-day. The phenotype columns provide the LEL values in mg/kg-day.
| Name | Sex | Liver Weight | Relative Liver Weight | Kidney Weight | Relative Kidney Weight | Decreased Hematocrit | Decreased Cholesterol | Decreased t3 | Decreased Free t4 | Decreased Total t4 | Plasma Conc. at Lowest LEL (ng/mL) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PFBS | female | 250 | 125 | NA | 62.6 | NA | 500 | 62.6 | 62.6 | 62.6 | 154.3 |
| PFBS | male | 125 | 62.6 | 500 | 500 | 62.6 | 62.6 | 62.6 | 62.6 | 62.6 | 2222 |
| PFDA | female | 0.156 | 0.156 | 0.312 | 0.625 | 1.25 | 1.25 | NA | 1.25 | NA | 11,207.8 |
| PFDA | male | 0.156 | 0.156 | 2.5 | 0.625 | NA | 0.156 | 0.312 | 0.312 | 0.312 | 8505 |
| PFHxA | female | 500 | 500 | 1000 | 1000 | 250 | 250 | NA | NA | NA | 475.4 |
| PFHxA | male | 500 | 250 | NA | 500 | 62.6 | 62.6 | 62.6 | 62.6 | 62.6 | 378.2 |
| PFHxSK | female | 3.12 | 3.12 | NA | NA | NA | NA | NA | 6.25 | 12.5 | 37,030 |
| PFHxSK | male | 1.25 | 1.25 | NA | 10 | NA | 1.25 | 0.625 | 0.625 | 0.625 | 66,760 |
| PFNA | female | 1.56 | 1.56 | 1.56 | 1.56 | NA | NA | 3.12 | 3.12 | 3.12 | 26,400 |
| PFNA | male | 0.625 | 0.625 | 2.5 | 1.25 | NA | 0.625 | 0.625 | 0.625 | 0.625 | 56,730 |
| PFOA | female | 25 | 25 | 50 | 100 | 6.25 | 50 | NA | 100 | 100 | 2960.1 |
| PFOA | male | 0.625 | 0.625 | 1.25 | 0.625 | 1.25 | 1.25 | 0.625 | 0.625 | 0.625 | 50,690.2 |
| PFOS | female | 0.312 | 0.312 | NA | NA | NA | 5 | 0.312 | 0.312 | 0.625 | 30,530 |
| PFOS | male | 0.312 | 0.312 | NA | NA | NA | 0.312 | 0.625 | 0.312 | 0.312 | 23,730 |