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. 2024 Apr 19;17(4):530. doi: 10.3390/ph17040530

Figure 2.

Figure 2

A novel object recognition (NOR) test was performed to detect the cognitive impairment of APP/PS1 mice. Data are represented as % of exploration time. On the training session (OF), the % of time spent exploring each of the familiar objects did not differ between control and cannabinoid receptor ligand-treated animals (p > 0.05). On the test day, 24 h following the training period, JG, JDG, and PG mice explored the novel object significantly more than the familiar object (p < 0.05), which indicated that cannabinoid receptor ligand therapy can improve NOR memory deficit in APP/PS1 mice. OF: training session using two identical objects (familiar objects); ON1: test session—evaluation of short-term memory, after an interval of 60 min; ON24: test session—evaluation of long-term memory, 24 h following the training period; ConG: control group; JG: JWH-133 group; JDG: JWH-133 + donepezil group; PG: Cannabixir® Medium Flos group; PDG: Cannabixir® Medium Flos + donepezil group; WT: vehicle group.