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. 2024 Apr 11;16(4):528. doi: 10.3390/pharmaceutics16040528

Figure 7.

Figure 7

Structural comparison of Dyk1A and Dyrk1B kinase domains. (A) Superposition of the AZ191-bound kinase domains of Dyrk1A (yellow; 8C3G) and Dyrk1B (green; 8C2Z) [101]. The bound AZ191 is shown in magenta or cyan for Dyrk1A or Dyrk1B, respectively. The phosphorylated tyrosine residues 321 or 273 of Dyrk1A or Dyrk1B, respectively, are shown in sticks on their activation loops. (B) Close-up view of important and identical polar interactions between AZ191 and Dyrk1A or Dyrk1B. The only difference in the ATP-binding site of these kinase domains is one residue in the hinge region (Dyrk1B-Leu 192 instead of Dyrk1A-Met 240). Images were created with PyMOL 1.8.0.4 version.