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. 2024 Apr 1;12(4):377. doi: 10.3390/vaccines12040377

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunoreactivity of RBD-specific IgG determined by the FCCA correlates with results obtained by ELISA. Scatter plots show a high correlation of anti-RBD IgG levels determined by the FCCA and ELISA against (A) RBD-Wuhan-Hu-1, (B) RBD-Delta, and (C) RBD-Omicron. Each symbol corresponds to a distinct sample and its color depicts the sample group to which it belongs. Sera were diluted 1:100 for the FCCA and 1:200 for the ELISA, respectively. The x-axes show log₁₀-transformed OD_(405–492) values obtained by ELISA, while the y-axes represent log₁₀-transformed ∆gMFI-APC values acquired with the FCCA. The horizontal blue color underlay represents the FCCA threshold, while the vertical ocher color underlay represents the ELISA threshold. Pearson’s correlation, ρ, and the linear regression line with 95% confidence intervals (dotted) are indicated in each graph.

Immunoreactivity of RBD-specific IgG determined by the FCCA correlates with results obtained by ELISA. Scatter plots show a high correlation of anti-RBD IgG levels determined by the FCCA and ELISA against (A) RBD-Wuhan-Hu-1, (B) RBD-Delta, and (C) RBD-Omicron. Each symbol corresponds to a distinct sample and its color depicts the sample group to which it belongs. Sera were diluted 1:100 for the FCCA and 1:200 for the ELISA, respectively. The x-axes show log₁₀-transformed OD_(405–492) values obtained by ELISA, while the y-axes represent log₁₀-transformed ∆gMFI-APC values acquired with the FCCA. The horizontal blue color underlay represents the FCCA threshold, while the vertical ocher color underlay represents the ELISA threshold. Pearson’s correlation, ρ, and the linear regression line with 95% confidence intervals (dotted) are indicated in each graph.